1. What is chemo-induced peripheral neuropathy?
Chemotherapy targets fast-dividing cancer cells and other healthy cells in the body, such as those in your bone marrow, the lining of your gastrointestinal tract and your hair follicles. In addition to its effect on rapidly dividing cells, chemotherapy may damage many healthy tissues, including peripheral nerves, leading to peripheral neuropathy.
2. What medications used in breast cancer treatment are commonly associated with CIPN?
Medications that are commonly used to treat myeloma, breast cancer, ovarian cancer, lung, brain and testicular cancers may lead to chemo-induced peripheral neuropathy. These may include platinum-based drugs, taxanes, Vinca alkaloids and Bortezomib. The frequency of chemotherapies and the potency of drugs increases the risk of neuropathy.
3. What are common peripheral neuropathy symptoms?
During and after chemotherapy treatment, 30–40% of patients may get chemotherapy-induced peripheral neuropathy, which causes tingling and numbness in the hands or feet. Many people will experience this side effect long after therapy is completed. In most cases, the symptoms will generally improve or go away within 6 to 12 months, but in some cases, the nerve damage is permanent. These symptoms typically begin during or after treatment and may worsen over time. CIPN can cause a range of other symptoms, including:
- Fatigue
- Difficulty sleeping
- Anxiety
- Depression
- Muscle cramps
- Weight loss
4. How can I manage peripheral neuropathy with breast cancer?
There is currently no cure for CIPN, but there are treatments that can help to ease the symptoms. Consult with your physician to find the best way to relieve your pain. Treatment options include medication, physical therapy and acupuncture. Treatments like cold therapy, electrical nerve stimulation and massage can also help to ease symptoms. There are a variety of medications that can be used to treat the symptoms of CIPN. These medications include pain relievers, antidepressants and topical treatments.
In some cases, the damage from CIPN is permanent. In these cases, treatment focuses on managing the symptoms and improving the quality of life. Managing CIPN symptoms can be a challenge. Some tips for pain management for those who suffer from CIPN include:
- Exercise
- Relaxation techniques
- Yoga
- Massage
- Transcutaneous electrical nerve stimulation (TENS)
Conclusion
With the right protocols and therapies, breast cancer patients can manage their peripheral neuropathy. Treatment plans are based on your specific type of neuropathy and other coexisting conditions. In addition, there are a variety of non-medications options that can be beneficial for some types of peripheral neuropathy.
WinSanTor is a clinical-stage biotechnology company focused on the discovery and development of treatments for peripheral neuropathies. We believe in creating a solution that works and brings relief to millions that are struggling with this disease. Learn more about our company, our drug and subscribe to our newsletter.
Sources
- “Breast Cancer Facts and Statistics”. BreastCancer.Org
- “Chemotherapy-Induced Peripheral Neuropathy: A Beginner’s Guide”. WinSanTor
- “Breast Cancer and Peripheral Neuropathy”. WinSanTor
- “Cancer Patients With Peripheral Neuropathy”. WinSanTor
