Beyond Pain Management: Breaking From the Past

Recent research from McGill University and Italian collaborators has prompted a reevaluation of the long-standing practice of treating acute pain with anti-inflammatory drugs. The study, published in Science Translational Medicine, indicates that this approach may unintentionally increase the risk of developing chronic pain. As a pharmaceutical company focused on reversing nerve damage, we are paying close attention to these findings.

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Older man with back pain.

The importance of understanding inflammation in pain resolution

Inflammation is more than a mere symptom of injury or infection. It plays a pivotal role in tissue repair and pain resolution, with neutrophils, a type of white blood cell, being particularly essential. These cells dominate the early stages of inflammation and lay the groundwork for tissue repair.

Unfortunately, many commonly used pain relief drugs, including steroids and non-steroidal anti-inflammatory drugs (NSAIDs), block inflammation and neutrophil activity. The study found that experimentally blocking neutrophils in mice led to pain lasting up to ten times longer than usual. Similarly, treating pain with anti-inflammatory drugs also prolonged pain, even though these drugs were initially effective.

The risks of blocking inflammation

An analysis of 500,000 individuals in the UK reinforced these findings, revealing that those who used anti-inflammatory drugs to manage pain were more likely to experience pain two to ten years later compared to those who took acetaminophen or anti-depressants.

A shift in pain management approaches

These findings suggest a need to reconsider how we differentiate chronic pain from acute pain. The study underscores the importance of understanding the chronic characteristics of diseases such as chronic pain, and the need for alternative relief methods. The research team noted that pain resolution is an active biological process, and further research and clinical trials are necessary to explore pain relief options that respect this process.

Conclusion

As a company dedicated to reversing nerve damage, we believe in staying updated on the latest findings in chronic diseases such as chronic pain. This study highlights the need for alternative lasting pain relief methods, such as this study, which looks at treatments that do not disrupt inflammation. We eagerly await further research that deepens our understanding of biological processes that affect pain resolution and offers more effective treatment options.

WinSanTor is a clinical-stage biotechnology company focused on the discovery and development of treatments for peripheral neuropathies. We believe in creating a solution that works and brings relief to millions that are struggling with this disease. Learn more about our companyour drug and subscribe to our newsletter.

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FAQs

Can inflammation cause chronic pain?

Inflammation is more than a mere symptom of injury or infection. It plays a pivotal role in tissue repair and pain resolution, with neutrophils, a type of white blood cell, being particularly essential. These cells dominate the early stages of inflammation and lay the groundwork for tissue repair.

What is the relationship between inflammation and chronic pain?

An analysis of 500,000 individuals in the UK reinforced these findings, revealing that those who used anti-inflammatory drugs to manage pain were more likely to experience pain two to ten years later compared to those who took acetaminophen or anti-depressants.

Can anti-inflammatory drugs cause chronic pain?

An analysis of 500,000 individuals in the UK reinforced these findings, revealing that those who used anti-inflammatory drugs to manage pain were more likely to experience pain two to ten years later compared to those who took acetaminophen or anti-depressants.

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WinSanTor is based in San Diego, California, USA

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