Paul is the chairman of the Department of Pharmacology & Therapeutics as well as a professor at the University of Manitoba. He is also the director of Division of Neurodegenerative Diseases at the St. Boniface Hospital Research Centre, Winnipeg. He has worked for 30 years on nerve cell biology and in the diabetic neuropathy field studying the etiology of the disease using in vitro and in vivo approaches. He invented the in vitro drug screen assay utilizing primary sensory neurons that identified the drugs currently under investigation.