Peripheral Neuropathy and Sleep

Peripheral neuropathy and sleep are two things that you may never think of as related, but they can be. There are a few ways that peripheral neuropathy can affect your sleep. Pain from neuropathy can keep you up at night and sleeping can be difficult when you experience symptoms. This can lead to a loss of sleep, which can, in turn, make the neuropathy worse.

Fortunately, you can do things to help improve your sleep if you are suffering from peripheral neuropathy. In this article, we’ll take a look at some ways to prepare for sleep while experiencing peripheral neuropathy symptoms. We’ll also explore the correlation between peripheral neuropathy and sleep.

Have you been diagnosed with peripheral neuropathy? We can help.

A young man not able to sleep at night and an alarm clock which indicates its early morning

How does sleep affect peripheral neuropathy symptoms?

Sleeping can be difficult while you are dealing with peripheral neuropathy symptoms. The pain and numbness can keep you up at night, and even if you can sleep, you may not be getting the rest you need.

Sleep can affect your peripheral neuropathy symptoms in a few ways. If you are not getting enough sleep, it can lead to fatigue and make neuropathy worse. Additionally, disrupted or poor-quality sleep can worsen neuropathy symptoms.

How sleep deprivation can affect pain threshold

An individual’s pain threshold is the point at which they feel pain. Research has shown that sleep deprivation can lower an individual’s pain threshold, meaning they will feel pain sooner than if they were well-rested.

When you are tired, your body produces more of the stress hormone cortisol, and cortisol can increase inflammation and make pain worse.

Why does peripheral neuropathy feel worse at night?

There are a few reasons why peripheral neuropathy feels worse at night. Numbness is a common symptom of peripheral neuropathy. When you are sleeping, the position of your body can affect how much numbness you experience. If you sleep on your side, you may find that the numbness in your arm or leg worsens. This is because gravity pulls the fluid and blood downward when you are lying down, which can cause the nerves to become compressed.

Why peripheral neuropathy may feel worse when lying down

Similar to sleeping, lying down can increase pressure on the nerves. When you are upright, your body’s weight is evenly distributed. However, when you are lying down, most of your weight is pressing down on one area. This can increase pressure on the nerves and cause pain.

Other reasons your neuropathy may feel worse when lying down or sleeping include:

  • Physical strain and effort, which might increase nerve discomfort as your body begins to relax
  • Exercise, especially vigorous exercise, which can lead to increased pain and discomfort
  • Lack of distractions at night, which may cause you to focus more on the pain you’re feeling

Peripheral neuropathy and sleeping tips to decrease discomfort and pain

If you’re experiencing pain and discomfort from peripheral neuropathy, you’re probably wondering if there is anything you can do to prepare for a good night’s rest or if there is anything you can do during the day to have good, pain-free sleep at night.

There are several things that you can do to improve your sleep when you have peripheral neuropathy. Some of the best tips for a more pain-free sleep include:

  • Create a regular sleeping schedule and stick to it as much as possible.
  • Make sure that your bedroom is dark, quiet, and cool — all of which can help promote better sleep.
  • Consider using a noise machine or a fan to create white noise, which can help block out distractions.
  • Make sure that you are getting enough exercise. When you are active, your body produces endorphins, which are natural painkillers.
  • Try using a pillow between your legs if you are sleeping on your side, or use a foam wedge to elevate your head and shoulders if you are sleeping on your stomach.


When it comes to sleep, peripheral neuropathy can make it challenging to get the rest that you need and deserve. However, by following these tips, you can create an environment that is more conducive to sleep, and by doing so, you may find that your symptoms improve.

WinSanTor is a clinical-stage biotechnology company focused on the discovery and development of treatments for peripheral neuropathies. We believe in creating a solution that works and brings relief to millions that are struggling with this disease. Learn more about our company, our drug and subscribe to our newsletter.


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